Lawrence H Boise Selected Research

Neoplasms (Cancer)

2/2024	Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells.
2/2024	KDM6A Regulates Immune Response Genes in Multiple Myeloma.
9/2023	Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma.
1/2023	Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy.
1/2023	Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
9/2021	Keeping Myeloma in Check: The Past, Present and Future of Immunotherapy in Multiple Myeloma.
1/2021	Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.
12/2020	Downregulation of PA28α induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma.
8/2019	Cancer Metabolism and the Evasion of Apoptotic Cell Death.
1/2019	Clinical efficacy of daratumumab, pomalidomide, and dexamethasone in patients with relapsed or refractory myeloma: Utility of re-treatment with daratumumab among refractory patients.

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Lawrence H Boise Research Topics

Disease

59	Multiple Myeloma 04/2024 - 01/2001
29	Neoplasms (Cancer) 02/2024 - 12/2002
3	Lymphoma (Lymphomas) 05/2015 - 03/2003
3	Acute Promyelocytic Leukemia 05/2009 - 01/2002
2	Hypersensitivity (Allergy) 04/2024 - 05/2010
2	Hematologic Neoplasms (Hematological Malignancy) 12/2023 - 12/2018
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2023 - 12/2018
2	Waldenstrom Macroglobulinemia (Macroglobulinemia) 11/2021 - 11/2011
2	Melanoma (Melanoma, Malignant) 01/2017 - 01/2017
2	Leukemia 01/2017 - 12/2003
2	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 02/2012 - 11/2011
2	Pancreatic Neoplasms (Pancreatic Cancer) 04/2011 - 12/2005
1	Genetic Translocation (Chromosomal Translocation) 04/2024
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/2023
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Carcinogenesis 12/2018
1	Myocarditis (Carditis) 01/2018
1	Colonic Neoplasms (Colon Cancer) 01/2017
1	Body Weight (Weight, Body) 05/2016
1	Wounds and Injuries (Trauma) 01/2014

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 12/2023 - 04/2011
10	Bortezomib (Velcade)FDA Link 04/2022 - 12/2005
10	Proteasome InhibitorsIBA 01/2022 - 06/2006
7	venetoclaxIBA 12/2023 - 12/2018
7	Arsenic Trioxide (Trisenox)FDA Link 01/2012 - 01/2002
5	Dexamethasone (Maxidex)FDA LinkGeneric 04/2022 - 06/2007
5	Glutathione (Reduced Glutathione)IBA 05/2014 - 12/2002
4	Immunoglobulins (Immunoglobulin)IBA 12/2020 - 05/2010
4	ArsenicIBA 01/2016 - 01/2001
3	Lenalidomide (CC 5013)FDA Link 04/2022 - 11/2019
3	Phosphotransferases (Kinase)IBA 11/2019 - 06/2005
3	darinaparsinIBA 01/2016 - 05/2009
2	Immunomodulating AgentsIBA 11/2023 - 09/2014
2	VaccinesIBA 09/2021 - 01/2019
2	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2020 - 08/2015
2	Serine (L-Serine)FDA Link 09/2017 - 09/2016
2	14- methyl- 20- oxa- 5,7,14,26- tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8(27),9,11,16,21,23- decaeneIBA 09/2017 - 01/2016
2	acetoacetic acid (acetoacetate)IBA 01/2017 - 01/2017
2	KetonesIBA 01/2017 - 01/2017
2	carfilzomibIBA 01/2016 - 05/2015
2	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2015 - 01/2012
2	Arsenicals (Arsenic Compounds)IBA 05/2014 - 05/2009
2	TransferasesIBA 02/2004 - 12/2003
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/2002 - 01/2001
1	Phosphates (Orthophosphate)IBA 04/2024
1	Histone MethyltransferasesIBA 04/2024
1	CreatineIBA 04/2024
1	Phosphocreatine (Neoton)IBA 04/2024
1	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 02/2024
1	Surface Antigens (Surface Antigen)IBA 02/2024
1	Histones (Histone)IBA 02/2024
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2023
1	Mevalonic Acid (Mevalonate)IBA 12/2023
1	Drug CombinationsIBA 09/2023
1	Exosome Multienzyme Ribonuclease ComplexIBA 01/2023
1	AntigensIBA 01/2023
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022
1	Immunoglobulin M (IgM)IBA 11/2021
1	ImidesIBA 09/2021
1	AntibodiesIBA 09/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	vendexIBA 01/2021
1	ChromatinIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Oncogene Proteins (Oncogene Protein)IBA 01/2021
1	Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)IBA 01/2021
1	Hormones (Hormone)IBA 01/2020
1	Docetaxel (Taxotere)FDA Link 01/2020
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2019
1	Chimeric Antigen ReceptorsIBA 01/2019
1	daratumumabIBA 01/2019
1	AZD5991IBA 12/2018
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2018
1	Cisplatin (Platino)FDA LinkGeneric 01/2018
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018
1	lestaurtinibIBA 01/2018
1	PlatinumIBA 01/2018
1	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	Dietary Fats (Dietary Fat)IBA 01/2017
1	Hydroxymethylglutaryl-CoA SynthaseIBA 01/2017
1	NucleotidesIBA 01/2017
1	Hypolipidemic Agents (Antihyperlipidemics)IBA 01/2017
1	3-hydroxy-3-methylglutaryl-coenzyme A lyase (HMG-CoA lyase)IBA 01/2017
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2017
1	5-carboxylcytosineIBA 01/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	dehydroacetic acid (DHAS)IBA 01/2017
1	EnzymesIBA 01/2017
1	BDA-366IBA 05/2016
1	ricolinostatIBA 05/2015
1	EicosanoidsIBA 01/2014
1	Arachidonic Acid (Vitamin F)IBA 01/2014

Therapy/Procedure

22	Therapeutics 02/2024 - 01/2002
5	Immunotherapy 02/2024 - 01/2018
5	Drug Therapy (Chemotherapy) 01/2017 - 01/2002
1	Stem Cell Transplantation 01/2019
1	Transplantation 01/2019
1	Radiotherapy 01/2018
1	Ketogenic Diet 01/2017